Organ-on-chip (OoC) technology has led to in vitro models with many new possibilities compared to conventional in vitro and in vivo models. In this review. the potential of OoC models to improve the prediction of human oral bioavailability and intrinsic clearance is discussed. with a focus on the functionality of the models and the application in current drug development practice. https://hollandscountryclothinges.shop/product-category/safety-shoes/